This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase. Other names in common use include O-succinyl-L-homoserine succinate-lyase (adding cysteine), O-succinylhomoserine (thiol)-lyase, homoserine O-transsuccinylase, O-succinylhomoserine synthase, O-succinylhomoserine synthetase, cystathionine synthase, cystathionine synthetase, homoserine transsuccinylase, 4-O-succinyl-L-homoserine:L-cysteine, and S-(3-amino-3-carboxypropyl)transferase. This enzyme participates in 4 metabolic pathways: methionine metabolism, cysteine metabolism, selenoamino acid metabolism, and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.
^Steegborn C, Laber B, Messerschmidt A, Huber R, Clausen T (August 2001). "Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor". Journal of Molecular Biology. 311 (4): 789–801. doi:10.1006/jmbi.2001.4880. PMID11518531.
Flavin M, Slaughter C (March 1967). "Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine". Biochimica et Biophysica Acta. 132 (2): 400–5. doi:10.1016/0005-2744(67)90158-1. PMID5340123.
Kaplan MM, Flavin M (October 1966). "Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis". The Journal of Biological Chemistry. 241 (19): 4463–71. PMID5922970.
Wiebers JL, Garner HR (January 1967). "Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity". The Journal of Biological Chemistry. 242 (1): 12–23. PMID6016326.
Wiebers JL, Garner HR (December 1967). "Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli". The Journal of Biological Chemistry. 242 (23): 5644–9. PMID12325384.