Cysteine dioxygenase (CDO, CAS number: 37256-59-0) is a mammalian non- heme iron enzyme that catalyzes the conversion of L- cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.
CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation
Cysteine sulfinic acid lies at a branch-point in
cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine ( 2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.
References [ edit ]
Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I (Feb 1976). "Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)". Biochimica et Biophysica Acta. 422 (2): 273–9. doi: 10.1016/0005-2744(76)90138-8. PMID 2307.
Chai SC, Jerkins AA, Banik JJ, Shalev I, Pinkham JL, Uden PC, Maroney MJ (Mar 2005). "Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase". The Journal of Biological Chemistry. 280 (11): 9865–9. doi: 10.1074/jbc.M413733200. PMID 15623508.
McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN (Feb 2006). "Structure and mechanism of mouse cysteine dioxygenase". Proceedings of the National Academy of Sciences of the United States of America. 103 (9): 3084–9. doi: 10.1073/pnas.0509262103. PMC 1413891 . PMID 16492780.
External links [ edit ]