Cytochalasin D

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cytochalasin D
Cytochalasin D.png
Names
Other names
Zygosporin A; Cytohalasin D; Lygosporin A
Identifiers
3D model (Jmol)
ChEBI
ChemSpider
ECHA InfoCard 100.040.716
Properties
C30H37NO6
Molar mass 507.63 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Cytochalasin D is a member of the class of mycotoxins known as cytochalasins. Cytochalasin D is an alkaloid produced by Helminthosporium and other molds.

Cytochalasin D is a cell-permeable and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It is believed to bind to F-actin polymer and prevent polymerization of actin monomers. [1]

References[edit]

  1. ^ Heptinstall, J. A. May H. Ratan J. R. Glenn W. L (1998). "GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly.". Platelets. 9 (3): 227–32. doi:10.1080/09537109876744. PMID 16793707. 

External links[edit]