Cytochrome b5 reductase

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cytochrome-b5 reductase
NADH cytochrome B5 reductase 1UMK.png
Ribbon diagram of erythrocytic methemoglobin reductase with FAD bound. From PDB: 1UMK​.
Identifiers
EC number1.6.2.2
CAS number9032-25-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Cytochrome b5 reductase
Identifiers
SymbolCYB5R
InterProIPR001834
Membranome421

Cytochrome-b5 reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:

NADH + H+ + 2 ferricytochrome b5 = NAD+ + 2 ferrocytochrome b5

The following four human genes encode cytochrome-b5 reductases:

See also[edit]

External links[edit]