Debulking is the reduction of as much of the bulk (volume) of a tumour as possible. It is usually achieved by surgical removal. It is also known as cytoreduction or cytoreductive surgery (CRS); "cytoreduction" refers to reducing the number of tumor cells. Debulking is used with curative intent in only some types of cancer, as generally partial removal of a malignant tumor is not a worthwhile intervention for curative purposes (because malignant cells left behind soon multiply and renew the threat). Ovarian cancer and some types of brain tumor are debulked before radiotherapy or chemotherapy begin, making those therapies more effective. It may also be used in the case of slow-growing tumors to shift tumor cells from phase of cell cycle to replicative pool.
In other types of cancer where debulking is not curative, it is sometimes done with palliative intent to relieve mass effect. For example, tumors whose bulk presses on the lungs or esophagus can impair breathing or swallowing, in which case debulking can improve quality of life and extend survival regardless of not curing the cancer.
Debulking procedures are usually long and often complicated, taking several hours or more to perform, depending on internal involvement and location.
- National Cancer Institute, NCI Dictionary of Cancer Terms: debulking, retrieved 2016-12-01.
- Silberman, AW (1982), "Surgical debulking of tumors", Surg Gynecol Obstet, 155 (4): 577–585, PMID 6750827.
- Johns Hopkins Medicine Department of Surgery, Cytoreductive Surgery and Heated Chemotherapy, retrieved 2016-12-01.
- American Cancer Society, Surgery for ovarian cancer, retrieved 2016-12-01.
- American Brain Tumor Association, Brain Tumor Surgery, retrieved 2016-12-01.
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