D-cysteine desulfhydrase

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D-cysteine desulfhydrase
EC number4.4.1.15
CAS number84012-74-8
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a D-cysteine desulfhydrase (EC is an enzyme that catalyzes the chemical reaction

D-cysteine + H2O sulfide + NH3 + pyruvate

Thus, the two substrates of this enzyme are D-cysteine and H2O, whereas its 3 products are sulfide, NH3, and pyruvate.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is D-cysteine sulfide-lyase (deaminating; pyruvate-forming). Other names in common use include D-cysteine lyase, and D-cysteine sulfide-lyase (deaminating). This enzyme participates in cysteine metabolism.


  • Nagasawa T, Ishii T, Kumagai H, Yamada H (1985). "D-Cysteine desulfhydrase of Escherichia coli. Purification and characterization". Eur. J. Biochem. 153 (3): 541–51. doi:10.1111/j.1432-1033.1985.tb09335.x. PMID 3908101.
  • Schmidt A (1982). "A cysteine desulfhydrase from spinach leaves specific for D-cysteine". Z. Pflanzenphysiol. 107: 301–312.
  • Schmidt A; Erdle I (1983). "A cysteine desulfhydrase specific for D-cysteine from the green-alga Chlorella fusca". Z. Naturforsch. C: Biosci. 38: 428–435.