D-xylose reductase

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D-xylose reductase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

D-xylose reductase (EC, XylR, XyrA, msXR, dsXR, monospecific xylose reductase, dual specific xylose reductase, NAD(P)H-dependent xylose reductase, xylose reductase) is an enzyme with systematic name xylitol:NAD(P)+ oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction

xylitol + NAD(P)+ D-xylose + NAD(P)H + H+

Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.


  1. ^ Neuhauser, W.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B. (1997). "NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme". Biochem. J. 326 (Pt 3): 683–692. PMC 1218722Freely accessible. PMID 9307017. 
  2. ^ Nidetzky, B.; Bruggler, K.; Kratzer, R.; Mayr, P. (2003). "Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies". J. Agric. Food Chem. 51 (27): 7930–7935. PMID 14690376. doi:10.1021/jf034426j. 
  3. ^ Iablochkova, E.N.; Bolotnikova, O.I.; Mikhailova, N.P.; Nemova, N.N.; Ginak, A.I. (2003). "The activity of xylose reductase and xylitol dehydrogenase in yeasts". Mikrobiologiia. 72 (4): 466–469. PMID 14526534. 
  4. ^ Chen, L.C.; Huang, S.C.; Chuankhayan, P.; Chen, C.D.; Huang, Y.C.; Jeyakanthan, J.; Pang, H.F.; Men, L.C.; Chen, Y.C.; Wang, Y.K.; Liu, M.Y.; Wu, T.K.; Chen, C.J. (2009). "Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (Pt 4): 419–421. PMC 2664776Freely accessible. PMID 19342796. doi:10.1107/S1744309109008719. 
  5. ^ Verduyn, C.; Van Kleef, R.; Frank, J.; Schreuder, H.; Van Dijken, J.P.; Scheffers, W.A. (1985). "Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis". Biochem. J. 226 (3): 669–677. PMC 1144764Freely accessible. PMID 3921014. doi:10.1042/bj2260669. 
  6. ^ Fernandes, S.; Tuohy, M.G.; Murray, P.G. (2009). "Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity". J. Biosci. 34 (6): 881–890. PMID 20093741. doi:10.1007/s12038-009-0102-7. 
  7. ^ Lee, J.K.; Koo, B.S.; Kim, S.Y. (2003). "Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis". Appl. Environ. Microbiol. 69 (10): 6179–6188. PMC 201247Freely accessible. PMID 14532079. doi:10.1128/AEM.69.10.6179-6188.2003. 
  8. ^ Woodyer, R.; Simurdiak, M.; van der Donk, W.A.; Zhao, H. (2005). "Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa". Appl. Environ. Microbiol. 71 (3): 1642–1647. PMC 1065158Freely accessible. PMID 15746370. doi:10.1128/AEM.71.3.1642-1647.2005. 

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