D2D may refer to:
- Device-to-device, a wireless standard in LTE-A for direct communication between user equipment
- Direct2D, a hardware-accelerated 2D API built on top of Direct3D 10
- Disk-to-disk, a Microsoft Operating System backup strategy
- Direct2Drive, an online video game and entertainment distributor and retail store
- Driver-to-Driver, a means of communication between people driving vehicles
- Door-to-door, a sales or political technique for engaging an audience
- Dot to Dot Festival, a music festival in the United Kingdom
- Delhi 2 Dublin, a Canadian world music band
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