DAB2

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DAB2
Protein DAB2 PDB 1m7e.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DAB2, DOC-2, DOC2, clathrin adaptor protein
External IDs MGI: 109175 HomoloGene: 1026 GeneCards: 1601
Genetically Related Diseases
Disease Name References
pancreatic cancer
RNA expression pattern
PBB GE DAB2 201278 at tn.png

PBB GE DAB2 201279 s at tn.png

PBB GE DAB2 201280 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001343
NM_001244871

NM_001008702
NM_001037905
NM_001102400
NM_023118
NM_001310446

RefSeq (protein)

NP_001231800.1
NP_001334.2

NP_001008702.1
NP_001032994.1
NP_075607.2

Location (UCSC) Chr 5: 39.37 – 39.46 Mb Chr 15: 6.3 – 6.44 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.[4][5]

Function[edit]

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).[6]

Interactions[edit]

DAB2 has been shown to interact with:

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_1793&geneId=33733". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R (January 1997). "Sequence, genomic structure, and chromosomal assignment of human DOC-2". Genomics. 33 (2): 207–13. doi:10.1006/geno.1996.0185. PMID 8660969. 
  5. ^ Mok SC, Chan WY, Wong KK, Cheung KK, Lau CC, Ng SW, Baldini A, Colitti CV, Rock CO, Berkowitz RS (June 1998). "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer". Oncogene. 16 (18): 2381–7. doi:10.1038/sj.onc.1201769. PMID 9620555. 
  6. ^ "Entrez Gene: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)". 
  7. ^ a b Zhou J, Scholes J, Hsieh JT (February 2003). "Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer". J. Biol. Chem. 278 (9): 6936–41. doi:10.1074/jbc.M210628200. PMID 12473651. 
  8. ^ a b He J, Xu J, Xu XX, Hall RA (July 2003). "Cell cycle-dependent phosphorylation of Disabled-2 by cdc2". Oncogene. 22 (29): 4524–30. doi:10.1038/sj.onc.1206767. PMID 12881709. 
  9. ^ Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785. 
  10. ^ a b Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC 162138free to read. PMID 12805222. 
  11. ^ Oleinikov AV, Zhao J, Makker SP (May 2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin". Biochem. J. 347 Pt 3: 613–21. doi:10.1042/0264-6021:3470613. PMC 1220996free to read. PMID 10769163. 
  12. ^ Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. 
  13. ^ Inoue A, Sato O, Homma K, Ikebe M (March 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161. 
  14. ^ a b Hocevar BA, Smine A, Xu XX, Howe PH (June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway". EMBO J. 20 (11): 2789–801. doi:10.1093/emboj/20.11.2789. PMC 125498free to read. PMID 11387212. 

Further reading[edit]