DAB2IP

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DAB2IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAB2IP, AF9Q34, AIP-1, AIP1, DIP1/2, DAB2 interacting protein
External IDsOMIM: 609205 MGI: 1916851 HomoloGene: 13058 GeneCards: DAB2IP
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for DAB2IP
Genomic location for DAB2IP
Band9q33.2Start121,567,057 bp[1]
End121,785,530 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032552
NM_138709

RefSeq (protein)

NP_115941
NP_619723

Location (UCSC)Chr 9: 121.57 – 121.79 MbChr 2: 35.56 – 35.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.[5][6][7]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM][7]

Interactions[edit]

DAB2IP has been shown to interact with DAB2.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136848 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026883 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen H, Pong RC, Wang Z, Hsieh JT (April 2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization". Genomics. 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990.
  6. ^ Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
  7. ^ a b "Entrez Gene: DAB2IP DAB2 interacting protein".
  8. ^ Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone Nora; Hsieh Jer-Tsong (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. ISSN 0021-9258. PMID 11812785.

Further reading[edit]