DAPK1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
DAPK1
Protein DAPK1 PDB 1ig1.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAPK1, DAPK, death associated protein kinase 1, ROCO3
External IDsMGI: 1916885 HomoloGene: 3626 GeneCards: DAPK1
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for DAPK1
Genomic location for DAPK1
Band9q21.33Start87,497,228 bp[1]
End87,708,633 bp[1]
RNA expression pattern
PBB GE DAPK1 211214 s at fs.png

PBB GE DAPK1 203139 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288729
NM_001288730
NM_001288731
NM_004938

NM_001285917
NM_029653
NM_134062

RefSeq (protein)

NP_001275658
NP_001275659
NP_001275660
NP_004929

NP_001272846
NP_083929
NP_598823

Location (UCSC)Chr 9: 87.5 – 87.71 MbChr 13: 60.6 – 60.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[5]

Function[edit]

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[6]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.[7]

As a drug target[edit]

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.[8] This has not been demonstrated in actual patients.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196730 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021559 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Sep 1995). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096. 
  6. ^ "Entrez Gene: DAPK1 death-associated protein kinase 1". 
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  8. ^ Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH (Jul 2015). "Death-associated protein kinase 1 promotes growth of p53-mutant cancers". The Journal of Clinical Investigation. 125 (7): 2707–20. doi:10.1172/JCI70805. PMC 4563671Freely accessible. PMID 26075823. 

Further reading[edit]