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Death-associated protein kinase 1
Protein DAPK1 PDB 1ig1.png
PDB rendering based on 1ig1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DAPK1 ; DAPK
External IDs OMIM600831 MGI1916885 HomoloGene3626 ChEMBL: 2558 GeneCards: DAPK1 Gene
EC number
RNA expression pattern
PBB GE DAPK1 203139 at tn.png
PBB GE DAPK1 211214 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1612 69635
Ensembl ENSG00000196730 ENSMUSG00000021559
UniProt P53355 Q80YE7
RefSeq (mRNA) NM_001288729 NM_001285917
RefSeq (protein) NP_001275658 NP_001272846
Location (UCSC) Chr 9:
87.5 – 87.71 Mb
Chr 13:
60.6 – 60.76 Mb
PubMed search [1] [2]

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[1]


Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[2]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.[3]

As a drug target[edit]

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.[4] This has not been demonstrated in actual patients.


  1. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Sep 1995). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096. 
  2. ^ "Entrez Gene: DAPK1 death-associated protein kinase 1". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH (Jul 2015). "Death-associated protein kinase 1 promotes growth of p53-mutant cancers". The Journal of Clinical Investigation 125 (7): 2707–20. doi:10.1172/JCI70805. PMID 26075823. 

Further reading[edit]