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Death-associated protein kinase 2
Protein DAPK2 PDB 1wmk.png
PDB rendering based on 1wmk.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DAPK2 ; DRP-1; DRP1
External IDs MGI1341297 HomoloGene74940 IUPHAR: 2003 ChEMBL: 3123 GeneCards: DAPK2 Gene
EC number
RNA expression pattern
PBB GE DAPK2 206324 s at tn.png
PBB GE DAPK2 215184 at tn.png
More reference expression data
Species Human Mouse
Entrez 23604 13143
Ensembl ENSG00000035664 ENSMUSG00000032380
UniProt Q9UIK4 Q8VDF3
RefSeq (mRNA) NM_014326 NM_010019
RefSeq (protein) NP_055141 NP_034149
Location (UCSC) Chr 15:
63.91 – 64.07 Mb
Chr 9:
66.16 – 66.27 Mb
PubMed search [1] [2]

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[1][2]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.[2] The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript. [3]


  1. ^ Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene 18 (23): 3471–80. doi:10.1038/sj.onc.1202701. PMID 10376525. 
  2. ^ a b "Entrez Gene: DAPK2 death-associated protein kinase 2". 
  3. ^ "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". 

Further reading[edit]