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Protein DAPK2 PDB 1wmk.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesDAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDsOMIM: 616567 MGI: 1341297 HomoloGene: 74940 GeneCards: DAPK2
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for DAPK2
Genomic location for DAPK2
Band15q22.31Start63,907,036 bp[1]
End64,072,033 bp[1]
RNA expression pattern
PBB GE DAPK2 206324 s at fs.png

PBB GE DAPK2 215184 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 15: 63.91 – 64.07 MbChr 9: 66.16 – 66.27 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[5][6]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.[6] The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000035664 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032380 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene. 18 (23): 3471–80. doi:10.1038/sj.onc.1202701. PMID 10376525.
  6. ^ a b "Entrez Gene: DAPK2 death-associated protein kinase 2".
  7. ^ Shoval, Yishay; Berissi, Hanna; Kimchi, Adi; Pietrokovski, Shmuel (2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE. 6 (2): e17344. doi:10.1371/journal.pone.0017344. PMC 3050894. PMID 21408167.

Further reading[edit]