DAPK3

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DAPK3
Protein DAPK3 PDB 1yrp.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDs MGI: 1203520 HomoloGene: 20353 GeneCards: DAPK3
RNA expression pattern
PBB GE DAPK3 203891 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001348

NM_001190473
NM_001190474
NM_007828

RefSeq (protein)

NP_001339.1

NP_001177402.1
NP_031854.1

Location (UCSC) Chr 19: 3.96 – 3.97 Mb Chr 10: 81.18 – 81.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[3][4]

Function[edit]

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[4]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[5]

Interactions[edit]

DAPK3 has been shown to interact with PAWR[6] and Death associated protein 6.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879Freely accessible. PMID 9488481. 
  4. ^ a b "Entrez Gene: DAPK3 death-associated protein kinase 3". 
  5. ^ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995Freely accessible. PMID 17953487. 
  6. ^ a b Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930Freely accessible. PMID 12917339. 

Further reading[edit]