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Death-associated protein kinase 3
Protein DAPK3 PDB 1yrp.png
PDB rendering based on 1yrp.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DAPK3 ; DLK; ZIP; ZIPK
External IDs OMIM603289 MGI1203520 HomoloGene20353 IUPHAR: 2004 ChEMBL: 2468 GeneCards: DAPK3 Gene
EC number
RNA expression pattern
PBB GE DAPK3 203891 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1613 13144
Ensembl ENSG00000167657 ENSMUSG00000034974
UniProt O43293 O54784
RefSeq (mRNA) NM_001348 NM_001190473
RefSeq (protein) NP_001339 NP_001177402
Location (UCSC) Chr 19:
3.96 – 3.97 Mb
Chr 10:
81.18 – 81.19 Mb
PubMed search [1] [2]

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[1][2]


Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[3]


DAPK3 has been shown to interact with PAWR[4] and Death associated protein 6.[4]


  1. ^ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481. 
  2. ^ a b "Entrez Gene: DAPK3 death-associated protein kinase 3". 
  3. ^ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genetics 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487. 
  4. ^ a b Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339. 

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