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DAZ associated protein 1

From Wikipedia, the free encyclopedia
(Redirected from DAZ (gene))
DAZAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAZAP1, DAZ associated protein 1
External IDsOMIM: 607430; MGI: 1917498; HomoloGene: 137331; GeneCards: DAZAP1; OMA:DAZAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018959
NM_170711
NM_001352033
NM_001352034
NM_001352035

NM_001122604
NM_001122605
NM_133188
NM_001378995

RefSeq (protein)

NP_061832
NP_733829
NP_001338962
NP_001338963
NP_001338964

NP_001116076
NP_001116077
NP_573451
NP_001365924

Location (UCSC)Chr 19: 1.41 – 1.44 MbChr 10: 80.1 – 80.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.[5][6]

Function

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In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[6]

Interactions

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DAZ associated protein 1 has been shown to interact with DAZ1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071626Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069565Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
  6. ^ a b "Entrez Gene: DAZAP1 DAZ associated protein 1".
  7. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Further reading

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