DAZ associated protein 1

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DAZAP1
Protein DAZAP1 PDB 2dgs.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases DAZAP1
External IDs HomoloGene: 137331 GeneCards: DAZAP1
RNA expression pattern
PBB GE DAZAP1 218443 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018959
NM_170711

n/a

RefSeq (protein)

NP_061832
NP_733829

n/a

Location (UCSC) Chr 19: 1.41 – 1.44 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.[2][3]

Function[edit]

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[3]

Interactions[edit]

DAZ associated protein 1 has been shown to interact with DAZ1.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750. 
  3. ^ a b "Entrez Gene: DAZAP1 DAZ associated protein 1". 
  4. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750. 

Further reading[edit]