DCP1A

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DCP1A
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DCP1A, HSA275986, Nbla00360, SMAD4IP1, SMIF, decapping mRNA 1A
External IDs MGI: 1923151 HomoloGene: 10178 GeneCards: 55802
RNA expression pattern
PBB GE DCP1A 218508 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018403
NM_001290204
NM_001290205
NM_001290206
NM_001290207

NM_133761

RefSeq (protein)

NP_001277133.1
NP_001277134.1
NP_001277135.1
NP_001277136.1
NP_060873.4

NP_598522.3

Location (UCSC) Chr 3: 53.28 – 53.35 Mb Chr 14: 30.48 – 30.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.[3]

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.[3]

Interactions[edit]

DCP1A has been shown to interact with DCP2[4] and UPF1.[4] It has also been shown to interact with GW182, a P-body marker.[5]

References[edit]

Further reading[edit]