DCTN1

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DCTN1
Protein DCTN1 PDB 1txq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DCTN1, DAP-150, DP-150, P135, dynactin subunit 1
External IDs MGI: 107745 HomoloGene: 3011 GeneCards: 1639
RNA expression pattern
PBB GE DCTN1 201082 s at tn.png

PBB GE DCTN1 211780 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198866
NM_001198867
NM_007835

RefSeq (protein)

NP_031861.2

Location (UCSC) Chr 2: 74.36 – 74.39 Mb Chr 6: 83.17 – 83.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.[3]

Function[edit]

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.[4]

Interactions[edit]

DCTN1 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Holzbaur EL, Hammarback JA, Paschal BM, Kravit NG, Pfister KK, Vallee RB (Jul 1991). "Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued". Nature. 351 (6327): 579–83. doi:10.1038/351579a0. PMID 1828535. 
  4. ^ "Entrez Gene: DCTN1 dynactin 1 (p150, glued homolog, Drosophila)". 
  5. ^ Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL (May 2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression". Nat. Genet. 36 (5): 462–70. doi:10.1038/ng1352. PMID 15107855. 
  6. ^ Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y (Oct 2003). "BPAG1n4 is essential for retrograde axonal transport in sensory neurons". J. Cell Biol. 163 (2): 223–9. doi:10.1083/jcb.200306075. PMC 2173519free to read. PMID 14581450. 
  7. ^ Sahni M, Zhou XM, Bakiri L, Schlessinger J, Baron R, Levy JB (Dec 1996). "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". J. Biol. Chem. 271 (51): 33141–7. doi:10.1074/jbc.271.51.33141. PMID 8955163. 
  8. ^ Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177. 

Further reading[edit]

External links[edit]