DDX1

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DDX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDDX1, DBP-RB, UKVH5d, DEAD/H-box helicase 1, DEAD-box helicase 1
External IDsOMIM: 601257 MGI: 2144727 HomoloGene: 3627 GeneCards: DDX1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DDX1
Genomic location for DDX1
Band2p24.3Start15,591,178 bp[1]
End15,631,111 bp[1]
RNA expression pattern
PBB GE DDX1 201241 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004939

NM_134040

RefSeq (protein)

NP_004930

NP_598801

Location (UCSC)Chr 2: 15.59 – 15.63 MbChr 12: 13.22 – 13.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene.[5][6]

Function[edit]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.[6]

Interactions[edit]

DDX1 has been shown to interact with HNRPK.[7] DDX1 has also been tentatively shown to interact with hCLE/C14orf166/RTRAF and HSPC117 in a cap-binding complex that activates mRNA translation. [8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079785 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037149 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Schmid SR, Linder P (February 1992). "D-E-A-D protein family of putative RNA helicases". Molecular Microbiology. 6 (3): 283–91. doi:10.1111/j.1365-2958.1992.tb01470.x. PMID 1552844.
  6. ^ a b "Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1".
  7. ^ Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K". The Journal of Biological Chemistry. 277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID 12183465.
  8. ^ Cho WJ, Yoon WJ, Moon CH, Cha SJ, Song H, Cho HR, Jang SJ, Chung DK, Jeong CS, Park JW (November 2002). "Molecular cloning of a novel chaperone-like protein induced by rhabdovirus infection with sequence similarity to the bacterial extracellular solute-binding protein family 5". The Journal of Biological Chemistry. 277 (44): 41489–96. doi:10.1074/jbc.M207104200. PMID 12183466.

Further reading[edit]