DDX1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DDX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DDX1, DBP-RB, UKVH5d, DEAD/H-box helicase 1
External IDs MGI: 2144727 HomoloGene: 3627 GeneCards: DDX1
RNA expression pattern
PBB GE DDX1 201241 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004939

NM_134040

RefSeq (protein)

NP_004930

NP_598801.1
NP_598801

Location (UCSC) Chr 2: 15.59 – 15.63 Mb Chr 12: 13.22 – 13.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene.[3][4]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.[4]

Interactions[edit]

DDX1 has been shown to interact with HNRPK.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schmid SR, Linder P (Apr 1992). "D-E-A-D protein family of putative RNA helicases". Mol Microbiol. 6 (3): 283–292. doi:10.1111/j.1365-2958.1992.tb01470.x. PMID 1552844. 
  4. ^ a b "Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1". 
  5. ^ Chen, Hui-Chin; Lin Wei-Chin; Tsay Yeou-Guang; Lee Sheng-Chung; Chang Ching-Jin (Oct 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K". J. Biol. Chem. United States. 277 (43): 40403–40409. doi:10.1074/jbc.M206981200. ISSN 0021-9258. PMID 12183465. 

Further reading[edit]