DDX10

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DDX10
Protein DDX10 PDB 2pl3.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDDX10, HRH-J8, DEAD-box helicase 10, Dbp4
External IDsMGI: 1924841 HomoloGene: 20922 GeneCards: DDX10
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for DDX10
Genomic location for DDX10
Band11q22.3Start108,665,025 bp[1]
End108,940,930 bp[1]
RNA expression pattern
PBB GE DDX10 204977 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004398

NM_029936

RefSeq (protein)

NP_004389

NP_084212

Location (UCSC)Chr 11: 108.67 – 108.94 MbChr 9: 53.1 – 53.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.[5][6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178105 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053289 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics. 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID 8660968. 
  6. ^ a b "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10". 

Further reading[edit]