Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10gene.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.
^Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics. 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID8660968.
Wang SC, Lien HC, Xia W, et al. (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.". Cancer Cell. 6 (3): 251–61. doi:10.1016/j.ccr.2004.07.012. PMID15380516.
Nakao K, Nishino M, Takeuchi K, et al. (2000). "Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome.". Intern. Med. 39 (5): 412–5. doi:10.2169/internalmedicine.39.412. PMID10830185.
Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets.". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID10655059.
Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts.". Int. J. Hematol. 69 (3): 160–4. PMID10222653.
Arai Y, Hosoda F, Kobayashi H, et al. (1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.". Blood. 89 (11): 3936–44. PMID9166830.