DDX11

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DDX11
Identifiers
Aliases DDX11, CHL1, CHLR1, KRG2, WABS, DEAD/H-box helicase 11
External IDs MGI: 2443590 HomoloGene: 68973 GeneCards: DDX11
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003919
NM_001348292

RefSeq (protein)

NP_001244073
NP_001244074
NP_004390
NP_085911
NP_689651

NP_001003919.1
NP_001003919
NP_001335221

Location (UCSC) Chr 12: 31.07 – 31.1 Mb Chr 17: 66.12 – 66.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.[3]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[3]

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