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AliasesDEF6, IBP, SLAT, SWAP70L, guanine nucleotide exchange factor, DEF6 guanine nucleotide exchange factor
External IDsOMIM: 610094 MGI: 1346328 HomoloGene: 11103 GeneCards: DEF6
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for DEF6
Genomic location for DEF6
Band6p21.31Start35,297,818 bp[1]
End35,321,771 bp[1]
RNA expression pattern
PBB GE DEF6 221293 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 35.3 – 35.32 MbChr 17: 28.21 – 28.23 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene.[5][6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000023892 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002257 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM (May 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". The Journal of Biological Chemistry. 284 (18): 11882–91. doi:10.1074/jbc.M809712200. PMC 2673257. PMID 19251698.
  6. ^ "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)".

Further reading[edit]

  • Oka T, Ihara S, Fukui Y (Jan 2007). "Cooperation of DEF6 with activated Rac in regulating cell morphology". The Journal of Biological Chemistry. 282 (3): 2011–8. doi:10.1074/jbc.M605153200. PMID 17121847.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F (Apr 2004). "DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA". Experimental Cell Research. 294 (2): 335–44. doi:10.1016/j.yexcr.2003.12.004. PMID 15023524.
  • Gupta S, Fanzo JC, Hu C, Cox D, Jang SY, Lee AE, Greenberg S, Pernis AB (Oct 2003). "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse". The Journal of Biological Chemistry. 278 (44): 43541–9. doi:10.1074/jbc.M308960200. PMID 12923183.
  • Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G, Pernis AB (Apr 2003). "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system". Human Immunology. 64 (4): 389–401. doi:10.1016/S0198-8859(03)00024-7. PMID 12651066.
  • Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A (Mar 2003). "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells". Immunity. 18 (3): 403–14. doi:10.1016/S1074-7613(03)00054-2. PMID 12648457.