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Defensin 3, dimer, Human.
PDB 1zmh EBI.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesDEFA3, DEF3, HNP-3, HNP3, HP-3, HP3, defensin alpha 3
External IDsOMIM: 604522 HomoloGene: 128756 GeneCards: DEFA3
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for DEFA3
Genomic location for DEFA3
Band8p23.1Start7,015,869 bp[1]
End7,018,297 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 8: 7.02 – 7.02 Mbn/a
PubMed search[2]n/a
View/Edit HumanView/Edit Mouse

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene.[3] Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.


Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This peptide differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.[3]


  1. ^ a b c ENSG00000284835 GRCh38: Ensembl release 89: ENSG00000239839, ENSG00000284835 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: defensin".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.