DEK (gene)

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DEK
Protein DEK PDB 1q1v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DEK, D6S231E, DEK proto-oncogene
External IDs MGI: 1926209 HomoloGene: 2593 GeneCards: DEK
RNA expression pattern
PBB GE DEK 200934 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134709
NM_003472

NM_025900

RefSeq (protein)

NP_001128181
NP_003463

NP_080176

Location (UCSC) Chr 6: 18.22 – 18.26 Mb Chr 13: 47.08 – 47.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

The human DEK gene encodes the DEK protein.[3][4]

Function[edit]

This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[4]

Interactions[edit]

DEK interacts with TFAP2A.[5]

References[edit]

Further reading[edit]