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Protein DGKA PDB 1tuz.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases DGKA, DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
External IDs MGI: 102952 HomoloGene: 1028 GeneCards: DGKA
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for DGKA
Genomic location for DGKA
Band 12q13.2 Start 55,927,319 bp[1]
End 55,954,027 bp[1]
RNA expression pattern
PBB GE DGKA 211272 s at fs.png

PBB GE DGKA 203385 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 12: 55.93 – 55.95 Mb Chr 12: 128.72 – 128.74 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.[5][6][7]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065357 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025357 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hart TC, Champagne C, Zhou J, Van Dyke TE (Jun 1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm Genome. 5 (2): 123–4. doi:10.1007/BF00292343. PMID 8180475. 
  6. ^ Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics. 22 (1): 246–7. doi:10.1006/geno.1994.1376. PMID 7959783. 
  7. ^ a b "Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa". 

Further reading[edit]

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