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Protein DGKD PDB 1r79.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases DGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta
External IDs MGI: 2138334 HomoloGene: 100054 GeneCards: DGKD
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DGKD
Genomic location for DGKD
Band 2q37.1 Start 233,354,507 bp[1]
End 233,472,104 bp[1]
RNA expression pattern
PBB GE DGKD 208072 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 233.35 – 233.47 Mb Chr 1: 87.85 – 87.95 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.[5][6][7]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.[7]


  1. ^ a b c ENSG00000280873 GRCh38: Ensembl release 89: ENSG00000077044, ENSG00000280873 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070738 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538. 
  6. ^ Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem. 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723. 
  7. ^ a b "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa". 

Further reading[edit]