DGKD

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DGKD
Protein DGKD PDB 1r79.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta
External IDsMGI: 2138334 HomoloGene: 100054 GeneCards: DGKD
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DGKD
Genomic location for DGKD
Band2q37.1Start233,354,507 bp[1]
End233,472,104 bp[1]
RNA expression pattern
PBB GE DGKD 208072 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003648
NM_152879

NM_177646

RefSeq (protein)

NP_003639
NP_690618

n/a

Location (UCSC)Chr 2: 233.35 – 233.47 MbChr 1: 87.85 – 87.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.[5][6][7]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.[7]

References[edit]

  1. ^ a b c ENSG00000280873 GRCh38: Ensembl release 89: ENSG00000077044, ENSG00000280873 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070738 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
  6. ^ Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem. 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723.
  7. ^ a b "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa".

Further reading[edit]