DGKG

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DGKG
Identifiers
Aliases DGKG, DAGK3, DGK-GAMMA, diacylglycerol kinase gamma
External IDs MGI: 105060 HomoloGene: 1029 GeneCards: DGKG
RNA expression pattern
PBB GE DGKG 206395 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001346
NM_001080744
NM_001080745

NM_138650
NM_001346673

RefSeq (protein)

NP_001074213
NP_001074214
NP_001337

NP_619591.1
NP_001333602
NP_619591

Location (UCSC) Chr 3: 186.11 – 186.36 Mb Chr 16: 22.47 – 22.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.[3][4]

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kai M, Sakane F, Imai S, Wada I, Kanoh H (Aug 1994). "Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells". J Biol Chem. 269 (28): 18492–8. PMID 8034597. 
  4. ^ a b "Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa". 

Further reading[edit]