DGKQ

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DGKQ
Identifiers
Aliases DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDs MGI: 102918 HomoloGene: 20352 GeneCards: DGKQ
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for DGKQ
Genomic location for DGKQ
Band 4p16.3 Start 958,887 bp[1]
End 986,895 bp[1]
RNA expression pattern
PBB GE DGKQ 207562 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001347

NM_199011
NM_001357029

RefSeq (protein)

NP_001338

NP_950176
NP_001343958

Location (UCSC) Chr 4: 0.96 – 0.99 Mb Chr 4: 108.65 – 108.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.[5][6][7]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[7]

Interactions[edit]

DGKQ has been shown to interact with RHOA.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145214 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004815 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502. 
  6. ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683. 
  7. ^ a b "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa". 
  8. ^ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. UNITED STATES. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731. 

Further reading[edit]