DGKZ

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DGKZ
Identifiers
Aliases DGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDs MGI: 1278339 HomoloGene: 37831 GeneCards: DGKZ
RNA expression pattern
PBB GE DGKZ 207556 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166597
NM_138306

RefSeq (protein)

NP_612179.2
NP_001160069
NP_612179

Location (UCSC) Chr 11: 46.33 – 46.38 Mb Chr 2: 91.93 – 91.98 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[3][4]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[4]

Interactions[edit]

DGKZ has been shown to interact with P110α.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem. 271 (17): 10230–6. doi:10.1074/jbc.271.17.10230. PMID 8626588. 
  4. ^ a b "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa". 
  5. ^ Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. United States. 278 (41): 39542–7. doi:10.1074/jbc.M307153200. ISSN 0021-9258. PMID 12890670. 

Further reading[edit]