dGTPase

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dGTPase
Identifiers
EC number3.1.5.1
CAS number9025-63-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a dGTPase (EC 3.1.5.1) is an enzyme that catalyzes the chemical reaction

dGTP + H2O deoxyguanosine + triphosphate

Thus, the two substrates of this enzyme are dGTP and H2O, whereas its two products are deoxyguanosine and triphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on triphosphoric monoester bonds. The systematic name of this enzyme class is dGTP triphosphohydrolase. Other names in common use include deoxy-GTPase, deoxyguanosine 5-triphosphate triphosphohydrolase, deoxyguanosine triphosphatase, and deoxyguanosine triphosphate triphosphohydrolase. This enzyme participates in purine metabolism.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1HA3, 2C77, 2C78, and 2DQB.

References[edit]

  • KORNBERG SR, LEHMAN IR, BESSMAN MJ, SIMMS ES, KORNBERG A (1958). "Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate". J. Biol. Chem. 233 (1): 159–62. PMID 13563461.
  • SETO D, BHATNAGAR SK, BESSMAN MJ (1988). "The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from E. coli". J. Biol. Chem. 263 (3): 1494–99. PMID 2826481.