DIAPH2

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DIAPH2
Identifiers
Aliases DIAPH2, DIA, DIA2, DRF2, POF, POF2, diaphanous related formin 2
External IDs HomoloGene: 136807 GeneCards: DIAPH2
RNA expression pattern
PBB GE DIAPH2 217246 s at fs.png

PBB GE DIAPH2 205726 at fs.png

PBB GE DIAPH2 205603 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007309
NM_006729

n/a

RefSeq (protein)

NP_006720
NP_009293

n/a

Location (UCSC) Chr X: 96.68 – 97.6 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Protein diaphanous homolog 2 is a protein that in humans is encoded by the DIAPH2 gene.[2][3]

Function[edit]

This gene may play a role in the development and normal function of the ovaries. Mutations of this gene have been linked to premature ovarian failure. Alternative splicing results in two protein isoforms.[3]

Interactions[edit]

DIAPH2 has been shown to interact with RhoD.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Lynch ED, Lee MK, Morrow JE, Welcsh PL, León PE, King MC (Dec 1997). "Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous". Science. 278 (5341): 1315–8. doi:10.1126/science.278.5341.1315. PMID 9360932. 
  3. ^ a b "Entrez Gene: DIAPH2 diaphanous homolog 2 (Drosophila)". 
  4. ^ Gasman S, Kalaidzidis Y, Zerial M (Mar 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064. 

Further reading[edit]