From Wikipedia, the free encyclopedia
Jump to: navigation, search
Death inducer-obliterator 1
Protein DIDO1 PDB 1wem.png
PDB rendering based on 1wem.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DIDO1 ; BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8
External IDs OMIM604140 MGI1344352 HomoloGene34139 GeneCards: DIDO1 Gene
RNA expression pattern
PBB GE DIDO1 218325 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11083 23856
Ensembl ENSG00000101191 ENSMUSG00000038914
UniProt Q9BTC0 Q8C9B9
RefSeq (mRNA) NM_001193369 NM_001291432
RefSeq (protein) NP_001180298 NP_001278361
Location (UCSC) Chr 20:
62.88 – 62.94 Mb
Chr 2:
180.66 – 180.71 Mb
PubMed search [1] [2]

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.[1][2]


Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[2]


  1. ^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development". Proc Natl Acad Sci U S A 96 (14): 7992–7. doi:10.1073/pnas.96.14.7992. PMC 22175. PMID 10393935. 
  2. ^ a b "Entrez Gene: DIDO1 death inducer-obliterator 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.