DIDO1

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DIDO1
Protein DIDO1 PDB 1wem.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DIDO1, BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8, death inducer-obliterator 1
External IDs MGI: 1344352 HomoloGene: 34139 GeneCards: 11083
RNA expression pattern
PBB GE DIDO1 218325 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291432
NM_001291433
NM_011805
NM_175551
NM_177852

RefSeq (protein)

NP_001278361.1
NP_001278362.1
NP_035935.2
NP_780760.2
NP_808520.2

Location (UCSC) Chr 20: 62.88 – 62.94 Mb Chr 2: 180.66 – 180.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.[1][2]

Function[edit]

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[2]

References[edit]

  1. ^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development". Proc Natl Acad Sci U S A 96 (14): 7992–7. doi:10.1073/pnas.96.14.7992. PMC 22175. PMID 10393935. 
  2. ^ a b "Entrez Gene: DIDO1 death inducer-obliterator 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.