DKK2

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DKK2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDs MGI: 1890663 HomoloGene: 8681 GeneCards: DKK2
RNA expression pattern
PBB GE DKK2 219908 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014421

NM_020265

RefSeq (protein)

NP_055236

NP_064661.2
NP_064661

Location (UCSC) Chr 4: 106.92 – 107.28 Mb Chr 3: 132.09 – 132.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene.[3][4]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA (Dec 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958. 
  4. ^ a b "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)". 

Further reading[edit]