DKK3

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
DKK3
Identifiers
AliasesDKK3, REIC, RIG, dickkopf WNT signaling pathway inhibitor 3
External IDsMGI: 1354952 HomoloGene: 8303 GeneCards: DKK3
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for DKK3
Genomic location for DKK3
Band11p15.3Start11,963,106 bp[1]
End12,009,769 bp[1]
RNA expression pattern
PBB GE DKK3 202196 s at fs.png

PBB GE DKK3 214247 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018057
NM_013253
NM_015881
NM_001330220

NM_015814
NM_001360257
NM_001360260
NM_001360261

RefSeq (protein)

NP_001018067
NP_001317149
NP_037385
NP_056965

NP_056629
NP_001347186
NP_001347189
NP_001347190

Location (UCSC)Chr 11: 11.96 – 12.01 MbChr 7: 112.12 – 112.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene.[5][6]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000050165 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030772 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA (Dec 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958. 
  6. ^ a b "Entrez Gene: DKK3 dickkopf homolog 3 (Xenopus laevis)". 

Further reading[edit]