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Protein DLG5 PDB 1uit.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases DLG5, LP-DLG, P-PDLG, discs large homolog 5, discs large MAGUK scaffold protein 5
External IDs MGI: 1918478 HomoloGene: 3486 GeneCards: DLG5
RNA expression pattern
PBB GE DLG5 201681 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 77.79 – 77.93 Mb Chr 14: 24.13 – 24.25 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Disks large homolog 5 is a protein that in humans is encoded by the DLG5 gene.[3][4]


This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.[4]


DLG5 has been shown to interact with SORBS3.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nakamura H, Sudo T, Tsuiki H, Miyake H, Morisaki T, Sasaki J, Masuko N, Kochi M, Ushio Y, Saya H (Sep 1998). "Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55". FEBS Lett. 433 (1-2): 63–7. doi:10.1016/S0014-5793(98)00882-5. PMID 9738934. 
  4. ^ a b "Entrez Gene: DLG5 discs, large homolog 5 (Drosophila)". 
  5. ^ Wakabayashi M, Ito T, Mitsushima M, Aizawa S, Ueda K, Amachi T, Kioka N (2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. PMID 12657639. 

Further reading[edit]