DLGAP4

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DLGAP4
Identifiers
Aliases DLGAP4, DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4, discs large homolog associated protein 4, DLG associated protein 4
External IDs MGI: 2138865 HomoloGene: 8935 GeneCards: DLGAP4
RNA expression pattern
PBB GE DLGAP4 202572 s at fs.png

PBB GE DLGAP4 202570 s at fs.png

PBB GE DLGAP4 202571 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042486
NM_014902
NM_183006

NM_001042487
NM_001042488
NM_001277186
NM_001277187
NM_146128

RefSeq (protein)

NP_001035951
NP_055717
NP_892118

Location (UCSC) Chr 20: 36.31 – 36.53 Mb Chr 2: 156.61 – 156.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.[3][4]

Function[edit]

DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (Jun 1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J Biol Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257. 
  4. ^ a b "Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4". 

Further reading[edit]