DLX1

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DLX1
Identifiers
Aliases DLX1, Dlx, Dlx-1, distal-less homeobox 1
External IDs MGI: 94901 HomoloGene: 22558 GeneCards: DLX1
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DLX1
Genomic location for DLX1
Band 2q31.1 Start 172,084,740 bp[1]
End 172,089,677 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001038493
NM_178120

NM_010053

RefSeq (protein)

NP_001033582
NP_835221

NP_034183

Location (UCSC) Chr 2: 172.08 – 172.09 Mb Chr 2: 71.53 – 71.53 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.[5][6]

Function[edit]

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144355 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041911 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348Freely accessible. PMID 7907794. 
  6. ^ a b "Entrez Gene: DLX1 distal-less homeobox 1". 

Further reading[edit]