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Distal-less homeobox 4
Symbols DLX4 ; BP1; DLX7; DLX8; DLX9
External IDs OMIM601911 MGI94904 HomoloGene7292 GeneCards: DLX4 Gene
RNA expression pattern
PBB GE DLX4 208216 at tn.png
PBB GE DLX4 210259 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1748 13394
Ensembl ENSG00000108813 ENSMUSG00000020871
UniProt Q92988 P70436
RefSeq (mRNA) NM_001934 NM_007867
RefSeq (protein) NP_001925 NP_031893
Location (UCSC) Chr 17:
49.97 – 49.97 Mb
Chr 11:
95.14 – 95.15 Mb
PubMed search [1] [2]

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.[1]


Many vertebrate homeobox-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.[1]


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.