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AliasesDNAJA2, CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2, DnaJ heat shock protein family (Hsp40) member A2
External IDsMGI: 1931882 HomoloGene: 21193 GeneCards: DNAJA2
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for DNAJA2
Genomic location for DNAJA2
Band16q11.2Start46,955,362 bp[1]
End46,973,788 bp[1]
RNA expression pattern
PBB GE DNAJA2 209157 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 16: 46.96 – 46.97 MbChr 8: 85.54 – 85.56 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.[5][6][7]

The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069345 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031701 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. PMC 109139. PMID 9710638.
  6. ^ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. ISSN 1466-1268. PMC 312896. PMID 11147971.
  7. ^ a b "Entrez Gene: DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2".

Further reading[edit]

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