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DnaJ (Hsp40) homolog, subfamily C, member 6
Protein DNAJC6 PDB 1n4c.png
PDB rendering based on 1n4c.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DNAJC6 ; DJC6; PARK19
External IDs OMIM608375 MGI1919935 HomoloGene8865 GeneCards: DNAJC6 Gene
EC number
Species Human Mouse
Entrez 9829 72685
Ensembl ENSG00000116675 ENSMUSG00000028528
UniProt O75061 Q80TZ3
RefSeq (mRNA) NM_001256864 NM_001164583
RefSeq (protein) NP_001243793 NP_001158055
Location (UCSC) Chr 1:
65.25 – 65.42 Mb
Chr 4:
101.5 – 101.64 Mb
PubMed search [1] [2]

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[1][2][3]


DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[3]


The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[4]


  1. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Oct 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. 
  2. ^ Ohtsuka K, Hata M (Apr 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. PMC 312896. PMID 11147971. 
  3. ^ a b "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6". 
  4. ^ Haynie DT, Xue B (Feb 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science 24: 874–82. doi:10.1002/pro.2664. PMID 25694109. 

Further reading[edit]