DNASE1L3

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DNASE1L3
Identifiers
Aliases DNASE1L3, DHP2, DNAS1L3, LSD, SLEB16, deoxyribonuclease I like 3
External IDs MGI: 1314633 HomoloGene: 3630 GeneCards: DNASE1L3
RNA expression pattern
PBB GE DNASE1L3 205554 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004944
NM_001256560

NM_007870

RefSeq (protein)

NP_001243489
NP_004935

NP_031896.3
NP_031896

Location (UCSC) Chr 3: 58.19 – 58.21 Mb Chr 14: 7.96 – 7.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.[3][4][5][6]

This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[6]

Homozygosity for a null allele results in systemic lupus erythematosus.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125. 
  4. ^ Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (Oct 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828. 
  5. ^ Shiokawa D, Hirai M, Tanuma S (Dec 2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506. 
  6. ^ a b "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3". 
  7. ^ Al-Mayouf, Sulaiman M; Sunker, Asma; Abdwani, Reem; Abrawi, Safiya Al; Almurshedi, Fathiya; Alhashmi, Nadia; Al Sonbul, Abdullah; Sewairi, Wafaa; Qari, Aliya; Abdallah, Eiman; Al-Owain, Mohammed; Al Motywee, Saleh; Al-Rayes, Hanan; Hashem, Mais; Khalak, Hanif; Al-Jebali, Latifa; Alkuraya, Fowzan S (2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–1188. doi:10.1038/ng.975. ISSN 1061-4036. 

Further reading[edit]