DNA polymerase delta

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DNA-directed DNA polymerase
EC number2.7.7.7
CAS number9012-90-2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4.[1] DNA Pol δ is an enzyme used for both leading and lagging strand synthesis.[2][3] It exhibits increased processivity when interacting with the proliferating cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the clamp loader for PCNA (which involves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.[citation needed]


  1. ^ Liu G, Warbrick E (October 2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochemical and Biophysical Research Communications. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
  2. ^ Johnson RE, Klassen R, Prakash L, Prakash S (July 2015). "A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands". Molecular Cell. 59 (2): 163–175. doi:10.1016/j.molcel.2015.05.038. PMC 4517859. PMID 26145172.
  3. ^ Lujan SA, Williams JS, Kunkel TA (September 2016). "DNA Polymerases Divide the Labor of Genome Replication". Trends in Cell Biology. 26 (9): 640–654. doi:10.1016/j.tcb.2016.04.012. PMC 4993630. PMID 27262731.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.