DNA polymerase nu

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POLN
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPOLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDsHomoloGene: 129696 GeneCards: POLN
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for POLN
Genomic location for POLN
Band4p16.3Start2,071,918 bp[1]
End2,242,121 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181808

n/a

RefSeq (protein)

NP_861524

n/a

Location (UCSC)Chr 4: 2.07 – 2.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.[3] It is a family A DNA polymerase,[4] considered to be the least effective of the polymerase enzymes.[5] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130997 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ "Entrez Gene: Polymerase (DNA directed) nu".
  4. ^ Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.
  5. ^ a b "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

Further reading[edit]