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Available structures
PDBOrtholog search: PDBe RCSB
AliasesDNM3, Dyna III, dynamin 3
External IDsOMIM: 611445 MGI: 1341299 HomoloGene: 22906 GeneCards: DNM3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DNM3
Genomic location for DNM3
Band1q24.3Start171,841,498 bp[1]
End172,418,466 bp[1]
RNA expression pattern
PBB GE DNM3 209839 at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 1: 171.84 – 172.42 MbChr 1: 161.98 – 162.48 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene.[5][6] The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.[7] DNM3 is upregulated in Sézary's syndrome.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197959 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040265 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. ^ "Entrez Gene: DNM3 dynamin 3".
  7. ^ Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
  8. ^ Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia. 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314.

Further reading[edit]