DNPEP

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Aspartyl aminopeptidase
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DNPEP ; ASPEP; DAP
External IDs OMIM611367 MGI1278328 HomoloGene6110 ChEMBL: 2761 GeneCards: DNPEP Gene
EC number 3.4.11.21
RNA expression pattern
PBB GE DNPEP 38703 at tn.png
PBB GE DNPEP 201937 s at tn.png
PBB GE DNPEP 217604 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23549 13437
Ensembl ENSG00000123992 ENSMUSG00000026209
UniProt Q9ULA0 Q9Z2W0
RefSeq (mRNA) NM_012100 NM_001110831
RefSeq (protein) NP_036232 NP_001104301
Location (UCSC) Chr 2:
219.37 – 219.4 Mb
Chr 1:
75.31 – 75.32 Mb
PubMed search [1] [2]

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.[1][2]

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins.[2]

Model organisms[edit]

Model organisms have been used in the study of DNPEP function. A conditional knockout mouse line called Dnpeptm1e(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]



References[edit]

  1. ^ Wilk S, Wilk E, Magnusson RP (Aug 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". J Biol Chem 273 (26): 15961–70. doi:10.1074/jbc.273.26.15961. PMID 9632644. 
  2. ^ a b "Entrez Gene: DNPEP aspartyl aminopeptidase". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M18.002