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Aspartyl aminopeptidase
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM611367 MGI1278328 HomoloGene6110 ChEMBL: 2761 GeneCards: DNPEP Gene
EC number
RNA expression pattern
PBB GE DNPEP 38703 at tn.png
PBB GE DNPEP 201937 s at tn.png
PBB GE DNPEP 217604 at tn.png
More reference expression data
Species Human Mouse
Entrez 23549 13437
Ensembl ENSG00000123992 ENSMUSG00000026209
UniProt Q9ULA0 Q9Z2W0
RefSeq (mRNA) NM_012100 NM_001110831
RefSeq (protein) NP_036232 NP_001104301
Location (UCSC) Chr 2:
219.37 – 219.4 Mb
Chr 1:
75.31 – 75.32 Mb
PubMed search [1] [2]

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.[1][2]

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins.[2]

Model organisms[edit]

Model organisms have been used in the study of DNPEP function. A conditional knockout mouse line called Dnpeptm1e(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]


  1. ^ Wilk S, Wilk E, Magnusson RP (Aug 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". J Biol Chem 273 (26): 15961–70. doi:10.1074/jbc.273.26.15961. PMID 9632644. 
  2. ^ a b "Entrez Gene: DNPEP aspartyl aminopeptidase". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M18.002