DOC2A

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DOC2A
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DOC2A, Doc2, double C2 domain alpha
External IDs MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A
RNA expression pattern
PBB GE DOC2A 205744 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282062
NM_001282063
NM_001282068
NM_003586

NM_010069

RefSeq (protein)

NP_001268991
NP_001268992
NP_001268997
NP_003577

NP_034199.1
NP_034199

Location (UCSC) Chr 16: 30.01 – 30.02 Mb Chr 7: 126.85 – 126.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[3][4][5]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.[5]

Interactions[edit]

DOC2A has been shown to interact with UNC13B[4][6] and UNC13A.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360. 
  4. ^ a b Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657Freely accessible. PMID 9736751. 
  5. ^ a b "Entrez Gene: DOC2A double C2-like domains, alpha". 
  6. ^ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900. 
  7. ^ "Protein unc-13 homolog A". UniProt. 

Further reading[edit]

  • Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557. 
  • Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738. 
  • Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.