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Available structures
PDB Ortholog search: PDBe RCSB
Aliases DOC2A, Doc2, double C2 domain alpha
External IDs MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A
Gene location (Human)
Chromosome 16 (human)
Chr. Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for DOC2A
Genomic location for DOC2A
Band 16p11.2 Start 30,005,509 bp[1]
End 30,023,270 bp[1]
RNA expression pattern
PBB GE DOC2A 205744 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 30.01 – 30.02 Mb Chr 16: 126.85 – 126.85 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[5][6][7]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.[7]


DOC2A has been shown to interact with UNC13B[6][8] and UNC13A.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149927 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052301 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. PMID 7826360. doi:10.1006/bbrc.1995.1062. 
  6. ^ a b Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. PMC 21657Freely accessible. PMID 9736751. doi:10.1073/pnas.95.19.11418. 
  7. ^ a b "Entrez Gene: DOC2A double C2-like domains, alpha". 
  8. ^ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. PMID 9195900. doi:10.1074/jbc.272.26.16081. 
  9. ^ "Protein unc-13 homolog A". UniProt. 

Further reading[edit]

  • Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. PMID 8554557. doi:10.1006/bbrc.1995.2876. 
  • Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. PMID 9115738. doi:10.1016/S0896-6273(00)81245-3. 
  • Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. PMID 9804756. doi:10.1074/jbc.273.46.30065.