DOK2

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DOK2
Protein DOK2 PDB 2d9w.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DOK2, p56DOK, p56dok-2, docking protein 2
External IDs MGI: 1332623 HomoloGene: 2957 GeneCards: 9046
RNA expression pattern
PBB GE DOK2 214054 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003974
NM_201349
NM_001317800

NM_010071

RefSeq (protein)

NP_003965.2

NP_034201.1

Location (UCSC) Chr 8: 21.91 – 21.91 Mb Chr 14: 70.77 – 70.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.[3]

Interactions[edit]

DOK2 has been shown to interact with INPP5D[4] and TEK tyrosine kinase.[5][6]

References[edit]

  1. ^ Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem 273 (9): 4827–30. doi:10.1074/jbc.273.9.4827. PMID 9478921. 
  2. ^ Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood 103 (6): 2088–95. doi:10.1182/blood-2003-07-2392. PMID 14645010. 
  3. ^ a b "Entrez Gene: DOK2 docking protein 2, 56kDa". 
  4. ^ Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173. 
  5. ^ Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820. 
  6. ^ Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432. 

Further reading[edit]