DOK5

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DOK5
Protein DOK5 PDB 1j0w.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDs MGI: 1924079 HomoloGene: 10195 GeneCards: 55816
RNA expression pattern
PBB GE DOK5 214844 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001294161
NM_018431
NM_177959

NM_001163686
NM_029761

RefSeq (protein)

NP_060901.2
NP_808874.1

NP_001157158.1
NP_084037.3

Location (UCSC) Chr 20: 54.48 – 54.65 Mb Chr 2: 170.73 – 170.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[2]

Interactions[edit]

DOK5 has been shown to interact with RET proto-oncogene.[1][3]

References[edit]

  1. ^ a b Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J Cell Biol 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823. 
  2. ^ a b "Entrez Gene: DOK5 docking protein 5". 
  3. ^ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081. 

Further reading[edit]