DOK5

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
DOK5
Protein DOK5 PDB 1j0w.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDsMGI: 1924079 HomoloGene: 10195 GeneCards: DOK5
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DOK5
Genomic location for DOK5
Band20q13.2Start54,475,597 bp[1]
End54,651,171 bp[1]
RNA expression pattern
PBB GE DOK5 214844 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001294161
NM_018431
NM_177959

NM_001163686
NM_029761

RefSeq (protein)

NP_001281090
NP_060901
NP_808874

NP_001157158
NP_084037

Location (UCSC)Chr 20: 54.48 – 54.65 MbChr 2: 170.73 – 170.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[6]

Interactions[edit]

DOK5 has been shown to interact with RET proto-oncogene.[5][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101134 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027560 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
  6. ^ a b "Entrez Gene: DOK5 docking protein 5".
  7. ^ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.

Further reading[edit]