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Available structures
PDB Ortholog search: PDBe RCSB
Aliases DPP10, DPL2, DPPY, DPRP-3, DPRP3, dipeptidyl peptidase like 10
External IDs MGI: 2442409 HomoloGene: 41400 GeneCards: DPP10
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DPP10
Genomic location for DPP10
Band 2q14.1 Start 114,442,299 bp[1]
End 115,845,752 bp[1]
RNA expression pattern
PBB GE DPP10 gnf1h06976 at fs.png

PBB GE DPP10 gnf1h06059 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 2: 114.44 – 115.85 Mb Chr 1: 123.32 – 124.05 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Inactive dipeptidyl peptidase 10 is a protein that in humans is encoded by the DPP10 gene.[5][6][7] Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]


This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties.[7]

Clinical significance[edit]

Mutations in this gene have been associated with asthma[7] and autism spectrum disorders.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175497 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036815 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  6. ^ Qi SY, Riviere PJ, Trojnar J, Junien JL, Akinsanya KO (Jun 2003). "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases". Biochem J. 373 (Pt 1): 179–89. doi:10.1042/BJ20021914. PMC 1223468Freely accessible. PMID 12662155. 
  7. ^ a b c d "Entrez Gene: DPP10 dipeptidyl-peptidase 10". 
  8. ^ Girirajan S, Dennis MY, Baker C, Malig M, Coe BP, Campbell CD, Mark K, Vu TH, Alkan C, Cheng Z, Biesecker LG, Bernier R, Eichler EE (February 2013). "Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder". Am. J. Hum. Genet. 92 (2): 221–37. doi:10.1016/j.ajhg.2012.12.016. PMC 3567267Freely accessible. PMID 23375656. 

Further reading[edit]