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Aliases DPP8, DP8, DPRP1, MSTP141, MST097, MSTP097, MSTP135, DPRP-1, dipeptidyl peptidase 8
External IDs MGI: 1921638 HomoloGene: 57098 GeneCards: DPP8
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for DPP8
Genomic location for DPP8
Band 15q22.31 Start 65,442,463 bp[1]
End 65,517,704 bp[1]
RNA expression pattern
PBB GE DPP8 220939 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 15: 65.44 – 65.52 Mb Chr 15: 65.03 – 65.08 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.[5][6]

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000074603 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032393 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD (Nov 2000). "Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8". Eur J Biochem. 267 (20): 6140–50. doi:10.1046/j.1432-1327.2000.01617.x. PMID 11012666. 
  6. ^ a b "Entrez Gene: DPP8 dipeptidyl-peptidase 8". 
Further reading